ABSTRACT
The aim of the present study was to investigate the changes in biochemical parameters including lipid profile, liver and kidney profile as well as oxidative stress profile, particularly in patients suffering from alcoholic liver disease [ALD]. Fifty chronic alcoholics admitted for treatment to the in-patient wards at Jinnah Hospital, Lahore-Pakistan. Chronic alcoholics with alcohol abuse for more than four to five years, and with or without clinical complications, were included. Apparently twenty healthy individuals served as control. 2012-2013. Various circulating biochemical biomarkers including renal profile, hepatic and lipid profile were evaluated. Moreover, stress markers [MDA. SOD, GSH and catalase] were also investigated. A very strong direct and indirect correlation of ALP was found with TB, MDA and GSH [r=.950**, r=.929** and r=-.967** respectively, P<0.01]. MDA was observed having very strong indirect correlation with GSH and catalase [r=-.909** and r-.777** respectively, P<0.01]. All parameters in combinations may be useful indicator or may be good and reliable biochemical markers for identification and determination of severity of alcoholic liver diseases [ALD]. The damaging of hepatocytes due to the consumption of alcohol disturbs almost all types of biochemical coordination in the biological system
Subject(s)
Humans , Oxidative Stress , Lipids , Liver Function Tests , Kidney Function TestsABSTRACT
Current study was conducted to determine the fluctuations of various circulating biomarkers including thyroid hormones, hepatic enzymes, oxidative stress markers as well as electrolytes in schizophrenics. Cross Sectional Study. This study was conducted at Psychiatric Clinic of Jinnah Hospital, Mental Hospital from Jan. 2013 to Oct. 2013. Seventy five acute schizophrenics and twenty five healthy individuals were selected for this study. Patients with chronic infections, diabetic history, liver disease or any other history of drugs including smoking and/or drinking alcohol were excluded from the study. Elevated levels of oxidative stress in the form of malondialdehyde [MDA] [7.8 +/- 2.71*] were observed in schizophrenics. Similarly raised levels of T3 [6.9 +/- 1.31*] and T4 [61.2 +/- 15.44*] were found in patients as compared to control. Electrolytes like Na, K, Ca and Mg showed alterations in the serum of both patients and control. All the circulating biochemical markers were statistically significant [P<0.05]. It is concluded that lipid peroxidation may has association with thyroid hormones and electrolytes. Moreover, alleviated concentration of anti-oxidant biomarkers like SOD, catalase and GSH may play a central role in schizophrenics and anti-oxidant therapy may be useful for the management of this psychiatric disorder